In the rats with liver fibrosis, the HGF/UC‐MSC transplant downregulated the expression of TGF‐β1, Smad2 and Smad3 more efficiently than UC‐MSCs,78 suggesting that the advantageous therapeutic efficacy of HGF/MSCs might depend on the TGF‐β/Smad signalling pathway. This evidence concerns the gene TGFB1 and Hepatic fibrosis.