HMGB1 and Hyperglycemia: Zhang et al. found that miR-126 expression in MSC-Exos reduced hyperglycemia-induced retinal inflammation by downregulating the HMGB1 signaling pathway, and MSC-Exos protected retinal neurons by downregulating the expression of NLRP3 inflammasome and NF-κB/P65 in a diabetic rat model [15].