Vats, L’s study showed that CA-IX was strongly expressed in renal clear cell carcinoma [19]; Ambrosio, MR’s study showed that CA-IX expression was positively correlated with prostate cancer grade and stage and outcome [20]; Supuran, CT [21] found that CA-IX was involved in the occurrence and migration of breast cancer. This evidence concerns the gene CA9 and Familial prostate cancer.