CXCL8 and cancer: In practice, several experimental evidences have documented that high expression of CXCL8 binds to receptors CXCR1 and CXCR2, mediates the transcriptional process of PI3K/Akt/mTOR signaling cascade, and promotes metastasis in multiple malignant tumors [39, 40], specifically in colon cancer [36, 41].