SLC22A11 and gout: Studies have shown that HPRT and PRPS1 gene mutations seem to be the main cause of primary gout [6]; SLC22A11 gene mutation is associated with RUE (renal underexcretion) gout [7]; ABCG2 seems to be one of the reasons for the genetic heterogeneity of ROL (renal overload) and RUE gout [8].