ALDH2 rs671 p.Glu504Lys pathogenic mutant reduces the activity of ALDH2, which is associated with reduced risk of gout [41].In addition, the rs671 GA + AA genotype was found to be associated with a lower risk of gout, while alcohol and BMI abnormalities were associated with a higher risk of gout in Taiwan population. This evidence concerns the gene ALDH2 and gout.