Recently, studies have found that HPRT pathogenic mutants c.103G > A (p.V35M) [12], c.277-281delATTGC, c.299 (exon 3) T > A, c.468-470delGAT and loss (exon: 6) 84 bp are related to family juvenile gout. The gene discussed is HPRT1; the disease is familial juvenile hyperuricemic nephropathy.