PLCG1 and cancer: Lastly, ten out of 96 (10%) recurrently mutated genes were known cancer genes according to COSMIC Cancer Gene Census v92: ARID2, BCL11B, BCOR, CDKN1B, DROSHA, FAT4, HIP1, NUTM1, PLCG1, and ROBO2 (Additional file 2: Fig. S4).