In accordance it was shown that S-phase kinase protein (Skp2) overexpression stimulates cytoplasmic localization of PPARγ through the MEK1-dependent pathway in breast cancer cells [39]; however, the mechanism of translocation and importance of cytoplasmic localization seemed to be tissue-dependent and is required to be clarified in other types of tumors such as bone tumors. The gene discussed is MAP2K1; the disease is breast cancer.