To be specific, no significant difference was observed in the PPARγ mRNA level in GCT (0.16 ± 0.09) tumors compared to the matched normal tumor margins (0.15 ± 0.09) (Fig. 1c); while osteosarcoma tumors expressed significantly higher level of PPARγ compared to normal bone tissues (P = 0.0039). This evidence concerns the gene PPARG and granular cell tumor.