As indicated, PPARγ gene expression showed significant diagnostic value to discriminate between malignant and benign bone tumors (Cut off value < 0.11, AUC = 0.68, P = 0.005), also between malignant and non-cancerous bone tissues (Cut off value < 0.13, AUC = 0.80, P < 0.0001) as well as bone tumors and bone normal tissues (Cut off value < 0.10, AUC = 0.70, P < 0.0001). Here, PPARG is linked to bone benign neoplasm.