PPARG and neoplasm: The tight linkage between PPARγ and cancer has attributed to the multi functions of PPARγ in metabolic reprogramming of cancer cells, tumor cell-associated secretions, tumor microenvironment and adaptations also immune response [11], however, the oncogenic or tumor suppressive role of PPARγ is controversial and dependent on the tumor cell type, origin, individual-specific manner and a dose concentration [12].