PTEN and non-small cell lung carcinoma: As shown in Tables 6 and 7, miR-197-3p is down-regulated in CRC and GC, where it targets TYMS and MTDH, which encodes a protein also involved in TYMS induction and PTEN repression, while in NSCLC and BRCA miR-197-3p is up-regulated because it also targets suppressor genes that are important in these cancers.