Also for miR-375-3p there is a miRNA response element in the 3’UTR of TYMS mRNA (see Table 1) and overexpression of miR-375 mimics in CRC cell lines increased their sensitivity to cytotoxic activity of 5FU in vitro and in tumor-bearing mice (Xu et al. 2020b). This evidence concerns the gene TYMS and colorectal carcinoma.