As a brief summary, Tables 12 and 13 show that down-regulation of miR-375-3p targeting FOXM1, TYMS, YAP1, PIK3CA, FZD8 can promote 5FU resistance of CRC cells, tumor growth and CRC metastasis by activating the PI3K/AKT and WNT/β-catenin signaling pathways. The gene discussed is AKT1; the disease is neoplasm.