CREB1 and hepatocellular carcinoma: From this overview, it can be seen that miR-433-3p targeting mRNA encoding the cAMP Response Element-Binding protein 1 (CREB1) has been found in cancer cells of various types including CRC, bladder cancer and HCC (Yan et al. 2018; Xu et al. 2016b; Yang et al. 2013).