However, miR-1307-3p also directly targets 3’UTR of TYMS mRNA and is significantly involved in the regulation of TS protein levels, as in CRC patients with low miR-1307-3p levels (due to T > C SNP in the terminal-loop of pre-miRNA) (Tang et al. 2015) elevated TS levels were reported along with insensitivity to capecitabine chemotherapy (Chen et al. 2017a). The gene discussed is TYMS; the disease is colorectal carcinoma.