CDC6 and hepatocellular carcinoma: Importantly, it has recently been shown that in highly aggressive hepatocellular carcinoma (HCC), miR-215-5p targets the 3’UTR of mRNA encoding Cell Division Cycle 6 (CDC6), which is involved in the assembly of the pre-replicative complex during the G1 phase of the cell cycle (Xu et al. 2020a).