On the other hand, a specific inhibitor of p38 pathway might counteract the tumor- accelerating effect induced by ICI on the basis that, in a former paper [16], we have suggested that the enhancing effect induced by a weak antitumor immune response was associated with the activation of TLR4 and p38 signaling pathways in macrophages recruited at the tumor place. The gene discussed is TLR4; the disease is neoplasm.