As described above, particular miRNAs could regulate major signaling pathways in the evolution of gliomas, including EGFR/RAS/NF1/PTEN/PI3K signaling and those related to p53, i.e. MDM2/MDM4/p14ARF and p16INK4a/CD4/RB1 pathways. Here, RB1 is linked to central nervous system cancer.