In glioma, miR-34a suppresses cell cycle progression and proliferation of glioma cells through direct inhibition of the expression of MET receptor tyrosine kinases (c-MET RTK), Notch-1, Notch-2, cyclin-dependent kinase 6 (CDK6), cyclin 1 (CCND1), and silent information regulator 1 (SIRT1) [99, 100]. Here, SIRT1 is linked to central nervous system cancer.