A growing body of evidence has shown that there is a close interaction between c-Myc and miRNAs, with c-Myc being one of the main regulators of miRNA expression; transcripts of a number of tumor suppressor miRNAs such as miR-15a/16-1, miR-26, miR-29, miR-30, miR-34a, and the let-7 family are repressed by c-Myc [49, 50]. This evidence concerns the gene MYC and neoplasm.