Similarly, JAK2/STAT3 activation or overexpression by adenoviral transfection of caSTAT3 into cardiomyocytes or transgenic mice construction can promote myocardial VEGF expression to regulate angiogenesis resulting in causal cardioprotection, which has been observed in MI, ischemia–reperfusion injury, HF, and other cardiac stress conditions (Sui et al. 2019; Dumont et al. 2000; Osugi et al. 2002). This evidence concerns the gene VEGFA and hydrops fetalis.