Deletion of S1R functions has been implicated with anti-angiogenic activity which reduced HUVECs’ survival (Crottès et al. 2016), moreover, S1R promotes the hERVG/β1-integrin signaling pathway to enhance the aggressive and pro-angiogenic capabilities of tumor cells (Niu et al. 2002). Here, TMBIM4 is linked to neoplasm.