Multiple neurodegenerative disorders such as AD, progressive supranuclear palsy (PSP), frontotemporal lobar degeneration (FTLD) and parkinsonism are characterized by intraneuronal aggregated tau inclusions caused by abnormal post-translational modification of tau protein as hyperphosphorylation and acetylation (Saha and Sen 2019; Zaki et al. 2022). The gene discussed is MAPT; the disease is Classical progressive supranuclear palsy.