MAPT and supranuclear palsy, progressive, 1: These mice exhibit synaptic pathology at age of 3 months, filamentous tau lesions at age of 6 months, motor impairments, neurodegeneration, microglial activation and present the clinical phenotypes of both (PSP) and (FTLD) (van Olst et al. 2020; Takeuchi et al. 2011; Yoshiyama et al. 2007).