MAPT and Alzheimer disease: Accumulation of acetylated tau in the human brain has been regularly detected in tau lesions from AD patients as well as a diversity of other human tauopathies, such as corticobasal degeneration, frontotemporal dementia, and PSP (Cohen et al. 2011; Irwin et al. 2012, 2013; Grinberg et al. 2013).