EIF2AK3 and age-related macular degeneration: In the context of previously observed EIF2AK3 downregulation and loss of Nrf2 signalling in AMD RPE, it is possible that PERK downregulation could impair Nrf2 signalling in AMD RPE, leaving cells unable to maintain redox homeostasis in a setting of impaired global translation attenuation and impaired apoptosis in response to ER stress16,37.