PRSS8 and diabetes mellitus: After multivariable adjustment in model 3, the HR for diabetes in the highest vs lowest quartile of prostasin was 1.76 (95% CI 1.41, 2.19; p for trend <0.0001) and that per 1 SD increase in prostasin was 1.23 (95% CI 1.13, 1.34; p<0.0001).