Unexpectedly, however, when KIM-1-deficient (KIM-1−/−) mice48 were injected intravenously with rAIM from day 1 of glyoxylate loading, the amount of kidney stones formed on day 6 was decreased to a level comparable to that observed in wild-type mice (Fig. 1g). Here, HAVCR1 is linked to nephrolithiasis.