For example, the Translational Research Investigating Biomarkers and End Points for Acute Kidney Injury (TRIBE-AKI) study investigated urine and plasma neutrophil gelatinase-associated lipocalin (uNGAL and pNGAL, respectively) in cardiac surgical patients and revealed only a moderate predictive performance of these well-investigated biomarkers (AUCROC: uNGAL: 0.67; pNGAL: 0.70)28. The gene discussed is LCN2; the disease is acute kidney injury.