NPM1 and acute myeloid leukemia: Due to these low sample sizes, we restricted further statistical analyses to the following genomic classes: NPM1, chromatin-spliceosome, no class, TP53-aneuploidy, and the core-binding factor (CBF) AML class [inv(16) and t(8;21)], thereby excluding a total of 24 patients in the smaller categories resulting in a total of 451 patients for analysis.