Estimated 4-year-survival rates were highest for CBF-AML (OS: 72%, EFS: 50%) followed by NPM1 classes (OS: 57%, EFS: 38%), whereas patients of the chromatin-spliceosome (OS: 33%, EFS: 16%), TP53-aneuploidy (OS: 35%, EFS: 6%), and no class (OS: 37%, EFS: 10%) groups had an adverse OS and EFS. This evidence concerns the gene NPM1 and acute myeloid leukemia.