FLT3 and acute myeloid leukemia: In conclusion, our targeted gene sequencing study in more than 450 patients with FLT3 mutation entered on the randomized CALGB 10603/RATIFY trial provides important and novel insights into the genomic background of FLT3-mutated AML, on prognostic impact of mutations co-occurring with FLT3 mutations as well as specific gene–gene interactions, and about possible treatment effects of midostaurin.