KRT18 and infection: As expected, 5′-ASO#26 treatment decreased the viral load of B.1.1.529 to nearly undetectable levels in the lungs of K18-hACE2 mice when compared with control treatment (Fig. 5f), and infection with B.1.1.529 (Omicron) did not induce significant weight loss in the control group (Fig. 5g).