KMT2D and Miyoshi myopathy: We extended the analysis to examine other genes recently implicated as MM drivers22, and strikingly, we observed multiple mutations in epigenetic modifiers of the lysine demethylase (KDM)/methyltransferase (KMT) family in patient #12, who presented with three clonal branches, KDM4B and KMT2D were each affected in a branch (Fig. 7 and Suppl.