VARS2 and Behcet disease: After stratifying HR individuals based on their personal burden of BD-associated common genetic variants indexed by BD-PRS and restricting the epigenome search space to variable probes with blood-brain correlation, we found a single epigenome-wide significant differentially methylated probe (cg00933603), located in an active regulatory element in exon 2 of the VARS2 gene, which lies in the major histocompatibility complex region (hg19/chr6:25–34 Mb).