Accordingly, the current study sought to elucidate the potential effect of CAFs-EVs carrying SNHG3 on CRC cell proliferation, and our findings revealed that CAFs-EVs carrying SNHG3 enhanced CRC cell proliferation via the miR-34b-5p/HuR/HOXC6 axis (Supplementary Fig. 2). Here, HOXC6 is linked to colorectal carcinoma.