Consistently, our findings illustrated that HOXC6 expression levels were enhanced in CRC cells, whereas treatment with CAFs-EVs or CAFs-EVs-SNHG3 further enhanced HOXC6 mRNA expression, while over-expression of miR-34b-5p led to a reduction in HOXC6 mRNA expression. This evidence concerns the gene SNHG3 and colorectal carcinoma.