Moreover, we found that HuR was highly expressed in CRC cells, while treatment with CAFs-EVs and CAFs-EVs-SNHG3 further enhanced the HuR expression, whereas miR-34b-5p over-expression reduced HuR expression levels (Fig. 6E, F and Supplementary Fig. 4). This evidence concerns the gene SNHG3 and colorectal carcinoma.