MYBPC3 and hypertrophic cardiomyopathy: With respect to the balance between protein synthesis and degradation, recent results from our laboratory demonstrated that heterozygous truncation mutations in the MYBPC3 gene, which cause hypertrophic cardiomyopathy, reduced the abundance of full-length MYBPC3 mRNA and the rate of MyBP-C synthesis in human induced pluripotent stem cells (48).