MUC16 and ovarian benign neoplasm: In the present study, ROC curves demonstrated that the combination of microRNA-204, CA125, and CA19.9 exhibited the strongest predictive ability for the early detection of ovarian cancer with AUCs of 0.938, 1.000, and 0.998 and cut-off values of 0.803, 0.500, and 0.742 for benign ovarian tumors, and early-stage, and late-stage ovarian cancers, respectively.