Since we were not able to conduct a complete around the clock study on T2D human islets due to the lack of material, lipid profiles were assessed at 2 opposite time points, 12 h and 24 h following synchronization by forskolin pulse (n = 5 T2D donors) and compared to the ND islet counterpart (n = 4, see Table 1 and S3 Data). This evidence concerns the gene CLOCK and type 2 diabetes mellitus.