MAPT and viral encephalitis: The poor sensitivity (60% in this study) and specificity (elevated CSF protein 14-3-3 levels have been reported in patients with viral encephalitis, hypoxic encephalopathy, metastases, and metabolic and paraneoplastic syndromes27,28,29,30) suggest that elevated CSF protein 14-3-3 levels have been supplanted by CSF measures of T-tau (affirmed in this study and others17) and RT-QuIC.