As in other tumor types, a pro-tumoral cytokine network induced by CD4+ T and myeloid-lineage cells in the TME, including prostaglandin E2 (PGE-2), IL-6, IL-10, and TGF-β, exacerbates the repression of effector CD8+ T cell response and induces Tregs [205]. This evidence concerns the gene TGFB1 and neoplasm.