Importantly, several mechanosensing signaling pathways have been demonstrated to be involved in the adaptive adjustment of the GBM TME, such as Hippo/YAP/TAZ, CD44, and actin skeleton signaling, which remodel the cytoskeleton and initiate biological processes including cell–cell/ECM interactions, proliferation, and migration/invasion of GBM cells, [83]. This evidence concerns the gene CD44 and glioblastoma.