CCL2 and glioma: In addition, since it is well-known that the CCL2/CCR2 axis is essential for monocyte migration into the inflamed CNS [123], another way to decrease TAM accumulation in GBMs might be to target the CCL2-CCR2 axis [90]. It has been speculated that CCR2-dependent myeloid cells also play crucial roles in controlling glioma growth.