Consistent with the important roles of p97/Cdc48/VCP in eukaryotic cell biology, dominant mutations in human p97 are associated with a late-onset multisystem proteinopathy (Johnson et al., 2010; Meyer and Weihl, 2014; Watts et al., 2004), whilst p97 is upregulated in certain cancer types (Li et al., 2021; Tsujimoto et al., 2004) and is a target for anti-cancer therapies (Anderson et al., 2015; Deshaies, 2014; Magnaghi et al., 2013; Wang et al., 2021). The gene discussed is VCP; the disease is Onset.