DSG1 and pemphigus foliaceus: These results suggest that the FcγR-mediated effector function can attenuate pathogenic anti-Dsg1 autoantibody-induced skin lesions by promoting the clearance of apoptotic keratinocytes that may otherwise undergo secondary necrosis and induce inflammation, and therefore contribute to the healing of Dsg1 autoantibody-induced skin lesions in PF models.