Interestingly, ‘non-pathogenic IgG1 anti-Dsg1 antibodies’ described in endemic PF patients in the preclinical stage and HC living in the endemic areas were proposed to have non-pathogenic binding epitopes (Aoki et al., 2015; Li et al., 2003), and no functional roles, as far as we know, have been proposed for the IgG1 subclass and these ‘non-pathogenic antibodies’. Here, DSG1 is linked to pemphigus foliaceus.