FURIN and allergic asthma: A large analysis on polygenic risk scores for asthma phenotypes found that there was a significant risk association for severe COVID-19, driven by non-allergic asthma, which remained significant after stratifying according to presence of COPD.19 Accordingly, increased transcript levels of FURIN, a host cell enzyme that enables activation of spike proteins, were found in neutrophilic asthma.20 In the present study, we were not able to determine asthma phenotypes, but we can hypothesize that there was high prevalence of non-allergic asthma, given the high proportion of COPD-asthma overlap.