That study also demonstrated that the transcriptional program regulated by TORC1/CREB and TORC1/AP1 complexes is activated in colonic cancer epithelial cells, and TORC1 was identified as a novel mediator of PGE2 signaling that promotes colorectal carcinogenesis and activation of the downstream pro‐tumorigenic targets in colon cancer.28, 29, 30. This evidence concerns the gene CREB1 and malignant colon neoplasm.