CREB1 and colonic neoplasm: That study also demonstrated that the transcriptional program regulated by TORC1/CREB and TORC1/AP1 complexes is activated in colonic cancer epithelial cells, and TORC1 was identified as a novel mediator of PGE2 signaling that promotes colorectal carcinogenesis and activation of the downstream pro‐tumorigenic targets in colon cancer.28, 29, 30