Among the 51 genes closely associated with the progression from HGIL to submucosal invasive cancer, we selected the following 3 reported to have a close relationship with colorectal carcinogenesis: target of rapamycin kinase complex 1 (TORC1; 19p13.11), mesothelin (MSLN; 16p13.3), and STIP1 homology and U‐box containing protein 1 (STUB1; 16p13.3). This evidence concerns the gene MSLN and medical procedure.