TERT and brain neoplasm: For example, a hypermethylated region of the TERT promoter known as THOR (TERT Hypermethylated Oncological Region) was first detected in a group of pediatric brain tumours and later shown to drive the expression of the TERT locus in various tumour types, such as in brain tumours, and in bladder, breast, colon, lung and prostate cancers [133, 134, 135].