Upon nutritional excess and physical activity deficit, adipocytes accumulate more fat, loose sensitivity to insulin and secrete less metabotrophic adipokines (e.g., adiponectin, nerve growth factor/NGF, and brain‐derived neurotrophic factor/BDNF), which leads to severe outcomes like atherosclerosis, metabolic syndrome and/or type 2 diabetes mellitus (T2DM).1, 3, 6. The gene discussed is NGF; the disease is metabolic syndrome.