We found histone mutations in HIST1H1B, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H1T, HIST1H2AJ, HIST1H2AM, HIST1H2BF, HIST1H3A, HIST1H3B, HIST1H4H, and HIST1H4L potentially expanding the landscape of oncohistone mutations in osteosarcoma (Table EV2 and Fig EV3; Nacev et al, 2020). This evidence concerns the gene H1-4 and osteosarcoma.