Together, these findings suggest that moderate inhibition of SOCE in Stim2‐deficient CD4+ T cells has no effect on colitogenic T cell function, whereas more pronounced inhibition of SOCE in Orai1 or Stim1‐deficient CD4+ T cells gradually suppresses inflammatory cytokine production and their ability to induce intestinal inflammation. The gene discussed is STIM1; the disease is inflammatory response.