Because of the potent suppressive effects of SOCE inhibition with BTP2 on the expression of proinflammatory cytokines and activation markers by human LPMCs and the reduced ability of Orai1 and Stim1‐deficient T cells to induce IBD in mice, we investigated if systemic treatment of mice with a selective CRAC channel inhibitor alleviates intestinal inflammation in mice. Here, ORAI1 is linked to inflammation.