The depletion of B cells producing IgA, which is required for the opsonization and neutralization of pathogenic bacteria in the gut, is likely to contribute to IBD in both UC and CD patients, a conclusion that is also supported by the increased frequency of IBD‐like inflammatory enteropathies in patients with common variable immunodeficiency and IgA deficiency (Shulzhenko et al, 2018; Rizvi et al, 2020). The gene discussed is CD79A; the disease is inflammatory bowel disease.