The pathophysiological importance of SOCE for immune function is emphasized by patients with loss‐of‐function mutations in STIM1 or ORAI1 genes, who suffer from combined immunodeficiency with recurrent infections (McCarl et al, 2009; Picard et al, 2009; Fuchs et al, 2012; Lacruz & Feske, 2015; Kahlfuss et al, 2020). Here, STIM1 is linked to infection.