Still, the mechanism of how diabetes affects BMD is not clear; however, metanalysis have reported decreased markers of bone formation osteocalcin, bone-specific alkaline phosphatase, collagen type 1 C propeptide, and increased markers of bone formation markers of bone resorption deoxypyridinoline, C terminal cross-linked telopeptide, and N-terminal cross-linked telopeptide of type-I collagen in diabetic subjects, suggesting disturbed bone remodeling.35 Here, BGLAP is linked to diabetes mellitus.