,36,37 Persons living with HIV with low CD4 count may also experience higher rates of early left ventricular hypertrophy and diastolic dysfunction38–40—precursors to clinical HF—and CD4 count appears inversely related to LVEF and markers of chronic inflammation associated with myocardial fibrosis and HF.41–44. Here, CD4 is linked to left ventricular hypertrophy.