In contrast to T cell deficiency, the recurrent tumors were significantly enriched for markers of tumor-associated neutrophils (TANs; eg., CD177, ELANE), tumor-associated macrophages (TAMs; eg., MRC1, CD68), and immune suppressive myeloid cells (MDSCs; eg., ARG1, CXCR4). Here, ELANE is linked to congenital T-cell immunodeficiency.