After 1:1 Propensity Score Matching, the viral-specific total antibody, IgG and IgM antibody of patients with COVID-19 were also higher than those of healthy vaccinated people (94.13 vs 4.65, 2.67 vs 0.44, 0.09 vs 0.06, respectively) (P < 0.001). This evidence concerns the gene CD40LG and COVID-19.