Univariate and multivariate analyses both revealed that the overall survival rate of OSCC patients was significantly linked to the expression of IGF2BP2 (p=0.003, 95% CI 1.213 to 2.644; p=0.039, 95% CI 1.530 to 2.289, respectively), histological grade (p=0.039, 95% CI 1.021 to 2.218), T status (p<0.001, 95% CI 1.239 to 2.139; p=0.013, 95% CI 1.132 to 2.887, respectively), lymph node metastasis (p<0.001, 95% CI 1.384 to 2.423; p=0.012, 95% CI 1.181 to 2.435, respectively) and stage (p<0.001, 95% CI 1.342 to 2.373). The gene discussed is IGF2BP2; the disease is metastatic malignant neoplasm in the lymph nodes.