IL1B and periodontitis: Among proinflammatory mediators, PGE2 and IL-1β play a major role in inflammatory processes which lead to the loss of the alveolar bone and the connective tissue in periodontal diseases.17-19 As a consequence of periodontitis, periodontal tissues are locally damaged and a large area of epithelium becomes wounded, allowing the exchange of products between the bacteria and the host.20