Therefore, a decrease in serum albumin levels due to various infectious processes is associated with increases in the levels of C-reactive protein and IgG.32,33 In addition, serum albumin might serve as an antioxidative agent in the inhibition of free radicals.34 Low albumin levels might result in changes in early cellular damage and initiation or exacerbation of irreversible degenerative processes, which is considered a prerequisite for inflammatory, ischemic and proliferative conditions.35 All the above might explain the relationship between serum albumin levels and chronic periodontitis. This evidence concerns the gene ALB and periodontitis.