Although the exact mechanism of the effect of periodontal disease on serum albumin levels is still unknown, it appears such relationship might be attributed to two hypotheses: the nutritional effects and the inflammatory effects of periodontal disease.27 Based on a study by Ogawa et al7 in 2006, the serum levels of albumin are associated with lower levels of total proteins, calcium, C-reactive protein and total cholesterol. The gene discussed is CRP; the disease is periodontal disorder.