HSPD1 and arthritic joint disease: In addition, our group has also used a recombinant Hsp65-producing Lactococcus lactis to prevent and treat inflammatory disease models such as EAE [14], DSS-induced colitis[142] and antigen-induced arthritis [81] showing that Hsp65-induced Tregs are able to inhibit inflammatory reactions towards myelin antigens, colonic antigens and collagen.