Studies on IL-36γ indicated that TLR4 can increase IL-36γ expression and can activate the signaling pathway of nuclear factor – KB (NF-KB) and MAPK (mitogen activated protein kinase).12 Since no study has been conducted on the effect of IL-36γ with the assessment of the effect of NF-KB factor on chronic condition of periodontitis, the present study investigated the effect of IL-36γ expression on chronic periodontitis through an increase in NF-KB signaling pathway. Here, TLR4 is linked to periodontitis.