Fitting these criteria, a considerable amount of effort has been put into the targeting of tumor-associated antigens (TAA) which are typically fetal or self-antigens (glypican-3, alpha-fetoprotein [AFP] and New York oesophageal squamous cell carcinoma-1 to name a few [17]) that are overexpressed in tumour development and low/absent in normal cells at steady state [18–20]. Here, AFP is linked to neoplasm.