Smoking, alcohol consumption and DM stood out as independent factors for isolated cirrhosis; while for cirrhosis with HCC alcoholism, DM, age, male gender, presence of polymorphic allele of CYP24A1-rs6013897 (_/T), viral hepatitis and altered serum levels of GGT, AFP and creatinine were the factors (Table 3). This evidence concerns the gene AFP and hepatocellular carcinoma.