In conclusion, the CYP24A1-rs6013897 polymorphism is associated with cirrhosis and HCC, standing out as a predictor of the disease, while the DBP-rs4588 polymorphism can influence in the reduction of vitamin D level in patients and, on the other hand, the variant DBP-rs7041 confers increased survival, suggesting a protective character. The gene discussed is CYP24A1; the disease is hepatocellular carcinoma.