The effect of genetic variants on the structure and activity of DBP stands out, influencing its affinity to vitamin D, as well as the concentration of 25(OH)D, as reported for the DBP polymorphisms rs7041 and rs458836. Incidentally, this study showed a higher frequency of reduced vitamin D levels in patients with cirrhosis with or without HCC carrying at least one mutant allele (_/A) for DBP-rs4588, compared to the control group, in agreement with Santos et al [37]. The gene discussed is DBP; the disease is Cirrhosis.