CD276 and lip and oral cavity carcinoma: Interestingly, tumors are capable of specifically modulate the glycosylation pattern of B7-H3 as shown for oral cancer which also has an impact on the interaction with their receptors.43 In this regard, it is entirely possible, that recombinant B7-H3 produced in HEK-cells does not mimic the necessary glycosylation pattern required to successfully perform a pull-down assay in our models.