Other SCLC cell lines expressing higher levels of p-AKT [i.e., p-AKT(S473) level > 0.7, Table 1], including NCI-H187, NCI-H446, and NCI-H69, were highly sensitive (IC50 < 100 nM) to treatment with GSK2126458 (Fig. 1B; Table 1). This evidence concerns the gene AKT1 and small cell lung carcinoma.