AKT1 and small cell lung carcinoma: Most of the SCLC cell lines that expressed lower AKT phosphorylation [i.e., p-AKT(S473) level < 0.2, Table 1] remained > 50% viable after treatment with 1.0 μM GSK2126458 (IC50 > 1.0 μM, including NCI-H211, NCI-H524, NCI-H526, NCI-H146, and NCI-H345).