For example, miR-29c has a binding site in the 3' UTR of VEGFA mRNA and can down-regulate the expression level of VEGFA, thereby promoting the capability of tumor cells to induce tube formation of human umbilical vein endothelial cells (HUVECs) in lung adenocarcinoma (LUAD) [39]. This evidence concerns the gene VEGFA and lung adenocarcinoma.