In the female infertility network, the top 3 hub genes identified were UPF3B, IRF8 and PSMB1. Copy number variation in the 6q27 region (which includes PSMB1) have been speculated to be the cause of premature ovarian failure (POF) in a patient from a POF cohort [22]. Here, IRF8 is linked to premature menopause.