CD274 and neoplasm: Furthermore, in the presence of irradiation, the levels of LINC00665, UCHL3, AhR and PD-L1 were up-regulated and miR-582-5p expression was down-regulated in the tumor tissues of mice injected with LINC00665 overexpressing cells; and additional AhR knockdown LINC00665 negated the increase in AhR and PD-L1 expression but showed no effects on miR-582-5p and UCHL3 expression (Fig. 7C).