With the aim to boost the efficacy of radiotherapy in NSCLC, this study elucidated a novel mechanism by which the LINC00665 augmented the stabilization of AhR protein through miR-582-5p-mediated regulation of the deubiquitylase UCHL3, thereby facilitating the immune escape of NSCLC cells and reducing radiosensitivity (Fig. 8). The gene discussed is AHR; the disease is non-small cell lung carcinoma.